AUTHOR=Ma Yuanyuan , Zhou Zhiyuan , Yang Guo-Yuan , Ding Jing , Wang Xin TITLE=The Effect of Erythropoietin and Its Derivatives on Ischemic Stroke Therapy: A Comprehensive Review JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.743926 DOI=10.3389/fphar.2022.743926 ISSN=1663-9812 ABSTRACT=

Numerous studies explored the therapeutic effects of erythropoietin (EPO) on neurodegenerative diseases. Few studies provided comprehensive and latest knowledge of EPO treatment for ischemic stroke. In the present review, we introduced the structure, expression, function of EPO, and its receptors in the central nervous system. Furthermore, we comprehensively discussed EPO treatment in pre-clinical studies, clinical trials, and its therapeutic mechanisms including suppressing inflammation. Finally, advanced studies of the therapy of EPO derivatives in ischemic stroke were also discussed. We wish to provide valuable information on EPO and EPO derivatives’ treatment for ischemic stroke for basic researchers and clinicians to accelerate the process of their clinical applications.