AUTHOR=Li Huixia , Zhang Liying , Tian Hong , Zhang Song , Zhang Xueyan , Zhang Han , Chen Yujing , Qi Wenping , Wu Xiaoying , Jiang Hongmei , Yang Hailong , Yang Yajun , Liu Lei , Zhang Guisen 

TITLE=Effect of 0.01% Atropine on Accommodation in Myopic Teenagers

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.808440

DOI=10.3389/fphar.2022.808440

ISSN=1663-9812

ABSTRACT=Purpose: In order to evaluate the effects of 0.01% atropine eye drops on accommodative system parameters among teenagers with low-myopia. 
Methods: 95 myopic teenagers (39 boys (8.69±2.473) and 56 girls (8.54±2.054) aged 5–17 years) with no history of eye disease were enrolled. Biometric and accommodative system parameters were evaluated before and 1 week, 1 month, 3 months as well as 6 months 0.01% atropine eye drops instillation.
Results: Participants without accommodative demand at 6 months demonstrated insignificant changes after the atropine instillation (all P > 0.05). However, there were significant differences in accommodative sensitivity, accommodative amplitude, accommodative responsiveness and negative relative accommodation (NRA) at 3 months compared with baseline after atropine instillation (all P < 0.05). Except spherical equivalent refraction, cornea thickness, intraocular pressure, and axial length were stable after the 0.01% atropine instillation (all P > 0.05).
Conclusions: Morphologically, current measurements suggested 0.01% atropine had favorable reduction of accommodation for childhood low myopia over a half-year period.