AUTHOR=Wang Anzhu , Zhao Wei , Yan Kaituo , Huang Pingping , Zhang Hongwei , Zhang Zhibo , Zhang Dawu , Ma Xiaochang TITLE=Mechanisms and Efficacy of Traditional Chinese Medicine in Heart Failure JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.810587 DOI=10.3389/fphar.2022.810587 ISSN=1663-9812 ABSTRACT=

Heart failure (HF) is one of the main public health problems at present. Although some breakthroughs have been made in the treatment of HF, the mortality rate remains very high. However, we should also pay attention to improving the quality of life of patients with HF. Traditional Chinese medicine (TCM) has a long history of being used to treat HF. To demonstrate the clinical effects and mechanisms of TCM, we searched published clinical trial studies and basic studies. The search results showed that adjuvant therapy with TCM might benefit patients with HF, and its mechanism may be related to microvascular circulation, myocardial energy metabolism, oxidative stress, and inflammation.