AUTHOR=Hu Xue , Zhang Qiang , Xing Wanying , Wang Wan 

TITLE=Role of microRNA/lncRNA Intertwined With the Wnt/β-Catenin Axis in Regulating the Pathogenesis of Triple-Negative Breast Cancer

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.814971

DOI=10.3389/fphar.2022.814971

ISSN=1663-9812

ABSTRACT=Malignant tumor formation is very high for breast cancer in women and a leading cause of death all over the globe. Among breast cancer subtypes, triple-negative breast cancer is rife in pre-menopausal women, most invasive, and prone to metastasis. Complex pathways are involved in the pathogenesis, advancement, and malignancy of this cancer, including the Wnt/β-catenin signaling pathway. This pathway is conserved among vertebrates and is necessary for sustaining cell homeostasis. It is regulated by several elements like transcription factors, enhancers, non-coding RNAs (lncRNAs, miRNAs), etc. In this mini-review, we discuss its modulation in triple-negative breast cancer, particularly the contribution of lncRNAs and miRNAs in its regulation and their possible entwining role with breast cancer pathogenesis, proliferation, migration, or malignancy.