AUTHOR=Feng Xing , Xiong Xiaoling , Ma Shenglin 

TITLE=Docetaxel-Loaded Novel Nano-Platform for Synergistic Therapy of Non-Small Cell Lung Cancer

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.832725

DOI=10.3389/fphar.2022.832725

ISSN=1663-9812

ABSTRACT=Today, non-small cell lung cancer (NSCLC) is threating the health of the whole people, and the current treatments are only marginally effective. So, the more low toxicity and efficient treatments are in sore need. In this paper, the smart nanoplat based on photothermal therapy, chemotherapy, and immunotherapy was constructed. The nanoparticles are composed of a novel photothermal agents, Mn-modified phthalocyanine derivative (MnIIIPC), docetaxel (DTX) and the effective targeting molecules, hyaluronic acid. The nano-platform could release the Mn2+ from MnIIIPC to activate tumor immunity through cGAS-STING and chemotherapy, respectively; furtherly, DTX was released in the process for removal of tumor cells. The "one-for-all" nanomaterial may shed some light on treating NSCLC in multiple methods.