AUTHOR=Ren Chunzhen , Liu Kai , Zhao Xinke , Guo Huan , Luo Yali , Chang Juan , Gao Xiang , Lv Xinfang , Zhi Xiaodong , Wu Xue , Jiang Hugang , Chen Qilin , Li Yingdong 

TITLE=Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.853289

DOI=10.3389/fphar.2022.853289

ISSN=1663-9812

ABSTRACT=Effective drugs for the treatment of myocardial fibrosis are lacking. Traditional Chinese medicine (TCM) has garnered increasing attention in recentyears for the prevention and treatment of myocardial fibrosis. This article describes the pathogenesis of myocardial fibrosis from the modern medicine, alongwith the research progress. Reports suggest that Chinese medicine may play a 
role in ameliorating myocardial fibrosis through different regulatory mechanismssuch as reduction of inflammatory reaction and oxidative stress, inhibition of 
cardiac fibroblast activation, reduction in extracellular matrix, renin–angiotensin–aldosterone system regulation, transforming growth Factorβ-1(TGF-β1) expression downregulation, TGF-β1/Smad signalling pathway regulation, and microRNAexpression regulation. Therefore, traditional Chinese medicine serves as a valuable source of candidate drugs for exploration of the mechanism of occurrence and development, along with clinical preventionand treatment of myocardialfibrosis.