AUTHOR=Song Chao , Yuan Yue , Zhou Jing , He Ziliang , Hu Yeye , Xie Yuan , Liu Nan , Wu Lei , Zhang Ji 

TITLE=Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.878937

DOI=10.3389/fphar.2022.878937

ISSN=1663-9812

ABSTRACT=Ginsenoside Rh2, a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity However, the mechanisms by which ginsenoside Rh2 induces apoptosis of lung cancer cells are unclear. A ginsenoside Rh2 target-lung cancer network was constructed and analyzed by the network pharmacology approach, identifying the PI3K-Akt signaling pathway. Ginsenoside Rh2 significantly inhibited proliferation and induced apoptosis and cell cycle arrest in A549 cells. Ginsenoside Rh2 inhibited the PI3K-Akt signaling pathway, consistent with the network pharmacology results. These findings will provide the potential therapeutic value for further mechanism investigations.