AUTHOR=Abdelgawad Shimaa M. , Hassab Mahmoud A. El , Abourehab Mohammed A. S. , Elkaeed Eslam B. , Eldehna Wagdy M. 

TITLE=Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.879118

DOI=10.3389/fphar.2022.879118

ISSN=1663-9812

ABSTRACT=Starting from December 2019, COVID-19 pandemic has caused a tremendous economic loss and unprecedented health crisis across the globe. Discovering an effective and safe drug candidate for the treatment of COVID-19 and its associated symptoms became a global urgent demand especially due to limited data that have been released regarding the vaccine efficacy and safety in humans. Reviewing the recent research, Olive leaf was selected as a potential co-therapy supplement for the treatment and improvement of clinical manifestations in COVID-19 patients. Olive leaves were reported to be rich in phenolic compounds such as Oleuropein, Hydroxytyrosol, Verbascoside, Apigenin-7-O-glucoside, Luteolin-7-O-glucoside, and also triterpenoids such as Maslinic, Ursolic and Oleanolic acids that have been reported as anti-SARS-CoV-2 metabolites in recent computational and in vitro studies.  Additionally, olive leaf extract was previously reported in several in vivo studies for its anti-inflammatory, analgesic, antipyretic, immunomodulatory and anti-thrombotic activities which is of a great benefit in the control of associated inflammatory cytokine storm and disseminated intravascular coagulation in COVID-19 patients. In conclusion, the described biological activities of olive leaves alongside with its biosafety, availability and low price, make it as a potential candidate drug or supplement to control COVID-19 infection and recommended for clinical investigation