AUTHOR=Palmer Mary E. , Andrews Lauren J. , Abbey Taylor C. , Dahlquist Ashley E. , Wenzler Eric 

TITLE=The importance of pharmacokinetics and pharmacodynamics in antimicrobial drug development and their influence on the success of agents developed to combat resistant gram negative pathogens: A review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.888079

DOI=10.3389/fphar.2022.888079

ISSN=1663-9812

ABSTRACT=A deep understanding of an antimicrobial’s critical pharmacokinetic and pharmacodynamic properties is crucial towards optimizing its use in patients and bolstering the drug development program. The complexity and rigor of PK and PD studies has improved dramatically in a short time span which has renewed confidence in the value of PK/PD and allowed it to become a fundamental component of a robust drug development program with a high chances of successful approval. A strong and dedicated focus on PK/PD throughout research and development leading the use of an optimized dosing regimen in Phase 3 trials will significantly improve the probability of approval and the confer maximum benefit to the patient for years to come.