AUTHOR=Adki Kaveri M. , Kulkarni Yogesh A. 

TITLE=Paeonol attenuates retinopathy in streptozotocin-induced diabetes in rats by regulating the oxidative stress and polyol pathway

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.891485

DOI=10.3389/fphar.2022.891485

ISSN=1663-9812

ABSTRACT=Current research work was planned to study the effects of paeonol in the management of diabetic retinopathy. Diabetes was induced in male Sprague Dawley rats using Streptozotocin (55 mg/kg, i.p.). After four weeks, diabetic animals were treated with paeonol at a dose of 50, 100 and 200 mg/kg body weight daily for the next 4 weeks. At the end of treatment, retinal physiology was studied by recording an electroretinogram (ERG); biochemical parameters and oxidative stress were estimated. Histopathology of the retina was also carried out at the end of the study. ERG of paeonol treated animals showed significant improvement in a-wave amplitude, b-wave amplitude, a-wave latency and b-wave latency (p<0.001) at 15 cd.s/m2 when compared with diabetic control animals. Paeonol treatment (200 mg/kg) showed a significant decrease in the plasma glucose level (p<0.001) compared to diabetic control. Paeonol also significantly decreased lactate dehydrogenase, aldose reductase and sorbitol dehydrogenase levels as compared with diabetic control. Oxidative stress in the eye was significantly (p<0.05) reduced after paeonol treatment in diabetic rats. Histopathology showed a significant reduction (p<0.05) in retinal thickness after paeonol treatment. Results of the study indicate that Paeonol can be considered an effective management option for diabetic retinopathy.