AUTHOR=Kurra Pallavi , Narra Kishore , Orfali Raha , Puttugunta Srinivasa Babu , Khan Shah Alam , Meenakshi Dhanalekshmi Unnikrishnan , Francis Arul Prakash , Asdaq Syed Mohammed Basheeruddin , Imran Mohd. 

TITLE=Studies on Jackfruit–Okra Mucilage-Based Curcumin Mucoadhesive Tablet for Colon Targeted Delivery

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.902207

DOI=10.3389/fphar.2022.902207

ISSN=1663-9812

ABSTRACT=The present work investigates a blend of jack fruit mucilage (JFM) and okra mucilage (OKM) as promising mucoadhesive carriers for colon-specific delivery of Curcumin (CMN) loaded mucoadhesive tablet (CMT) formulation. Formulation optimization was performed using central composite design (CCD) to further decipher the effect of varying proportions of the mucoadhesive carriers JFM and OKG on response factors such as drug release (% DR) and mucoadhesive strength (MA). The optimized formulation CMT (F14) exhibited favorable 54.35% in vitro release of CMN in 12 h with, the release kinetics ensuing zero-order anomalous diffusion mechanism and MA of 34.1733 ± 1.26g. Accelerated stability testing of CMT (F14) confirmed a shelf life of about 4.7 years. In vivo drug targeting studies performed using rabbit models to observe transit behavior (colon-specific delivery) of the dosage form were assessed by fluoroscopic images of the GI tract. Taken together, the results confirm that the combination of JFM and OKM could be exploited as an ideal mucoadhesive carrier for the effective delivery of the macromolecules to the colon.