AUTHOR=Miri Amir Hossein , Kamankesh Mojtaba , Llopis-Lorente Antoni , Liu Chenguang , Wacker Matthias G. , Haririan Ismaeil , Asadzadeh Aghdaei Hamid , Hamblin Michael R. , Yadegar Abbas , Rad-Malekshahi Mazda , Zali Mohammad Reza 

TITLE=The Potential Use of Antibiotics Against Helicobacter pylori Infection: Biopharmaceutical Implications

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.917184

DOI=10.3389/fphar.2022.917184

ISSN=1663-9812

ABSTRACT=Helicobacter pylori is a notorious, recalcitrant and silent germ, which can cause a variety of debilitating stomach diseases, including gastric and duodenal ulcers and gastric cancer. This microbe predominantly colonizes the mucosal layer of the human stomach and survives in the inhospitable gastric microenvironment, by adapting to this hostile milieu. In this review, we first discuss H. pylori colonization and invasion. Thereafter, we provide a survey of current curative options based on polypharmacy, looking at pharmacokinetics, pharmacodynamics and pharmaceutical microbiology concepts, in the battle against H. pylori infection.