AUTHOR=Li Yeling , Wang Huimei , Liu Wenhui , Hou Jiantong , Xu Jing , Guo Yuanqiang , Hu Ping 

TITLE=Cratoxylumxanthone C, a natural xanthone, inhibits lung cancer proliferation and metastasis by regulating STAT3 and FAK signal pathways

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.920422

DOI=10.3389/fphar.2022.920422

ISSN=1663-9812

ABSTRACT=To obtain bioactive natural products as lead compounds for cancertreatment, cratoxylumxanthone C, a natural xanthone was obtained from Cratoxylum cochinchinense (Lour.) Bl., which has not been reported on its anti-tumor effects in vivo and in vitro. Our study revealed that cratoxylumxanthone C had significant anti-tumor activity by inducing cell apoptosis, increasing ROS production, and arresting cell cycle at G0/G1 stage. The mechanic examination showed cratoxylumxanthone C inhibited A549 cell proliferation and migration via regulating STAT3 and FAK signaling pathways. Furthermore, it inhibited cell proliferation and migration in a zebrafish xenograft model, and inhibited tumor angiogenesis in zebrafish in vivo. Collectively, these cellular and zebrafish results suggested that cratoxylumxanthone C may be considered as an anticancer agent for lung cancer, especially non-small cell lung cancer (NSCLC).