AUTHOR=He Tianmu , Ao Jingwen , Duan Cancan , Yan Rong , Li Xiaomei , Liu Liu , Zhang Jianyong , Li Xiaofei 

TITLE=Bibliometric and visual analysis of nephrotoxicity research worldwide

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.940791

DOI=10.3389/fphar.2022.940791

ISSN=1663-9812

ABSTRACT=Background: Nephrotoxicity of drugs contributes to acute kidney injury with high mortality and morbidity, which crucially limits the application and development of drugs. Although many publications of nephrotoxicity have been conducted globally, there need a scientometric study to systematically analyze the intellectual landscape and frontiers research trends in the future. 
Methods: Publications of nephrotoxicity from 2011 to 2021 were collected to perform bibliometric visualization using VOSviewer, CiteSpace, and Scimago Graphica software based on the Web of Science Core Collection. 
Results: A total of 9,342 documents were analyzed, which were primarily published in the USA (1,861), China (1,724), Egypt (701); and for institutions, King Saud University (166) had the most publications; Food and Chemical Toxicology, PLoS One, and Antimicrobial Agents and Chemotherapy were productive journals, primarily concentrating on the mechanisms of nephrotoxicity and renoprotective in cisplatin and antibiotics, especially in oxidative stress. Burst detection suggested that cisplatin, piperacillin-tazobactam, vancomycin-induced nephrotoxicity, antioxidant, and new biomaterials are frontiers research.
Conclusion: This study firstly provides an updated perspective on nephrotoxicity and renoprotective strategies and mechanisms. This perspective may benefit researchers in choosing suitable journals and collaborators, and assist them in the deeply understanding of the nephrotoxicity and renoprotective hotspots and frontiers.