AUTHOR=Feng Zuxi , Ou Yanghuan , Hao Liang 

TITLE=The roles of glycolysis in osteosarcoma

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.950886

DOI=10.3389/fphar.2022.950886

ISSN=1663-9812

ABSTRACT=Metabolic reprogramming is of great significance in the progression of various cancers and is critical for cancer progression, diagnosis and treatment. Cellular metabolic pathways mainly include glycolysis, fat metabolism, glutamine decomposition, and oxidative phosphorylation. In cancer cells, reprogramming metabolic pathways is used to meet the massive energy requirement for tumorigenesis and development. Metabolisms are also altered in malignant osteosarcoma (OS) cells. Among reprogrammed metabolisms, alterations in aerobic glycolysis are key to the massive biosynthesis and energy demands of OS cells to sustain their growth and metastasis. Many studies have proved that compared to normal cells, glycolysis in OS cells under aerobic conditions is substantially enhanced to promote malignant behaviors such as proliferation, invasion, metastasis, and drug resistance of OS. Glycolysis in OS is closely related to various oncogenes and tumor suppressor genes, and numerous signaling pathways have been reported to be involved in the regulation of glycolysis. This article focused on key proteins and signaling pathways involved in regulating aerobic glycolysis in OS cells to expound on the close relationship between glycolysis and the progression of OS and to discover novel therapeutic approaches targeting glycolytic metabolism in OS.