AUTHOR=Chen Wenjian , Wang Jianpeng , Yang Huaizhi , Sun Yuankai , Chen Bangjie , Liu Yuchen , Han Yanxun , Shan Ming , Zhan Junfeng TITLE=Interleukin 22 and its association with neurodegenerative disease activity JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.958022 DOI=10.3389/fphar.2022.958022 ISSN=1663-9812 ABSTRACT=

It is worth noting that neuroinflammation is well recognized as a symptom of neurodegenerative diseases (NDs). The regulation of neuroinflammation becomes an attractive focus for innovative ND treatment technologies. There is evidence that IL-22 is associated with the development and progression of a wide assortment of NDs. For example, IL-22 can activate glial cells, causing them to generate pro-inflammatory cytokines and encourage lymphocyte infiltration in the brain. IL-22 mRNA is highly expressed in Alzheimer’s disease (AD) patients, and a high expression of IL-22 has also been detected in the brains of patients with other NDs. We examine the role of IL-22 in the development and treatment of NDs in this review, and we believe that IL-22 has therapeutic potential in these diseases.