AUTHOR=Huang Anqi , Wang Xuanxuan , Tao Yun , Lin Likai , Cheng Hong TITLE=Healthcare professionals’ knowledge, attitude and practice towards National Centralized Drug Procurement policy in central China: A cross-sectional study JOURNAL=Frontiers in Pharmacology VOLUME=Volume 13 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.996824 DOI=10.3389/fphar.2022.996824 ISSN=1663-9812 ABSTRACT=Background: National Centralized Drug Procurement (NCDP), an ongoing government-led policy starting in 2019 in China, aimed at reducing drug costs. During the implementation of NCDP, healthcare professionals (HCPs) still have a certain degree of concern about the policy, which affects the clinical use of related drugs. Objective: This study aims to assess the level of knowledge, attitude and practice (KAP) of HCPs towards NCDP policy, together with the associated factors that determine their KAP. Methods: A cross-sectional study was conducted between September and November of 2021 in 30 hospitals in Hubei province in Central China. A self-designed online questionnaire including KAP towards NCDP policy was administered to HCPs. Logistic regression analysis was adopted to identify the factors associated with KAP. Results: Totally, 742 HCPs completed the questionnaires. 43.4% of HCPs had good knowledge, 24.7% had positive attitude, and 23.7% held good practice. Through multivariate logistic regression analysis, HCPs who are males, pharmacists, with senior professional titles and 6-10 professional working experience contributed to higher knowledge level. Pharmacists and HCPs with good knowledge were more likely to have positive attitude, while HCPs with higher education were less likely to have positive attitude. Pharmacists, HCPs who had 11-20 professional working experience, worked in medium-size urban areas or had good knowledge were more likely to have good practice. Good practice is also associated with the positive attitudes towards the efficacy of centralized-purchased medicines and impacts of NCDP policy. Conclusion: Only a small percentage of HCPs have good KAP towards NCDP policy. Pharmacists showed better KAP than physicians. The positive attitudes towards the efficacy of centralized-purchased medicines and impacts of NCDP policy contribute to better practice. High-quality clinical evidences on the therapeutic effects and safety of the centralized-purchased drugs are needed.