AUTHOR=Kamaruzzaman Mohd Amir , Romli Muhammad Hibatullah , Abas Razif , Vidyadaran Sharmili , Hidayat Baharuldin Mohamad Taufik , Nasaruddin Muhammad Luqman , Thirupathirao Vishnumukkala , Sura Sreenivasulu , Warsito Kabul , Mohd Nor Nurul Huda , Azwaruddin Muhammad Amsyar , Alshawsh Mohammed Abdullah , Mohd Moklas Mohamad Aris 

TITLE=Regulatory role of the endocannabinoid system on glial cells toward cognitive function in Alzheimer’s disease: A systematic review and meta-analysis of animal studies

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1053680

DOI=10.3389/fphar.2023.1053680

ISSN=1663-9812

ABSTRACT=The purpose of this systematic review gain a conclusive properties of endocannabinoid towards cognition in animal studies by looking at the mechanism modulated on glial cells. Six database were searched encompassing including EBSCOHost, Scopus, PubMed, CINAHL, Cochrane, and Web of Science. Twenty-six studies were identified to be fit into inclusion criteria. Once obtained the included studies were assessed for the quality using SYRCLE's risk of bias tool. We can conclude that glial cell modulated by endocannabinoid promotes cognitive improvement in Alzheimer's disease like animal model.