AUTHOR=Gorin Boris I. , Tukhovskaya Elena A. , Ismailova Alina M. , Slashcheva Gulsara A. , Lenina Oksana A. , Petrov Konstantin A. , Kazeev Ilya V. , Murashev Arkady N. TITLE=Differences in bioavailability and cognitive-enhancing activity exerted by different crystal polymorphs of latrepirdine (DimebonĀ®) JOURNAL=Frontiers in Pharmacology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1091858 DOI=10.3389/fphar.2023.1091858 ISSN=1663-9812 ABSTRACT=Pharmacokinetic characteristics as well as cognitive-enhancing nootropic activity of latrepirdine (DimebonĀ®) in relationship with its polymorphic forms have been studied in SD and Wistar rats. It was shown that the crystalline structure (polymorphism) has direct impact on latrepirdine bioavailability and pharmacological activity. A new polymorph of latrepirdine with enhanced pharmaceutical properties, namely Polymorph E, has been discovered.