AUTHOR=Ochoa Sara V. , Casas Zulma , Albarracín Sonia L. , Sutachan Jhon Jairo , Torres Yolima P. 

TITLE=Therapeutic potential of TRPM8 channels in cancer treatment

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1098448

DOI=10.3389/fphar.2023.1098448

ISSN=1663-9812

ABSTRACT=The transient receptor potential melastatin 8 (TRPM8) channel is a nonselective cation channel expressed in neuronal and non-neuronal tissues, where is involved in several processes including thermosensation, differentiation, and migration. TRPM8 channels also participate in physiological processes related to cancer as proliferation, survival, and invasion. Prostate cancer is the best-described cancer and these channels have an important role in diagnosis, prognosis, and treatment. In addition, it has been reported that TRPM8 channels are involved in the progress of pancreatic, breast, bladder, colon, gastric, and skin cancer as well as glioblastoma and neuroblastoma. Cancer is a multifactorial process associated with changes in signaling pathways leading to variations in cell cycle and gene expression. In this review, we summarize the current knowledge on the role of TRPM8 channels in cancer progression. We also include a discussion about the therapeutic potential of TRPM8 in carcinogenesis, which has been proposed as a cancer biomarker and molecular target for cancer therapy.