AUTHOR=Li Yanwen , Zhu Yongwei , Chen Long , Xia Shunjin , Adegboro Abraham Ayodeji , Wanggou Siyi , Li Xuejun 

TITLE=Transcription factor ZBTB42 is a novel prognostic factor associated with immune cell infiltration in glioma

JOURNAL=Frontiers in Pharmacology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1102277

DOI=10.3389/fphar.2023.1102277

ISSN=1663-9812

ABSTRACT=<p><bold>Background:</bold> ZBTB42 is a transcription factor that belongs to the ZBTB transcript factor family and plays an important role in skeletal muscle development. Dysregulation of ZBTB42 expression can lead to a variety of diseases. However, the function of ZBTB42 in glioma development has not been studied by now.</p><p><bold>Methods:</bold> We analyzed the expression of ZBTB42 in LGG and GBM <italic>via</italic> the The Cancer Genome Atlas CGA and Chinese Glioma Genome Atlas database. Gene Ontology, KEGG, and GSVA analyses were performed to illustrate ZBTB42-related pathways. ESTIMATE and CIBERSORT were applied to calculate the immune score and immune cell proportion in glioma. One-class logistic regression OCLR algorithm was used to study the stemness of glioma. Multivariate Cox analysis was employed to detect the prognostic value of five ZBTB42-related genes.</p><p><bold>Results:</bold> Our results show that ZBTB42 is highly expressed in glioma and may be a promising prognostic factor for Low Grade Glioma and GBM. In addition, ZBTB42 is related to immune cell infiltration and may play a role in the immune suppression microenvironment. What’s more, ZBTB42 is correlated with stem cell markers and positively associated with glioma stemness. Finally, a five genes nomogram based on ZBTB42 was constructed and has an effective prognosis prediction ability.</p><p><bold>Conclusion:</bold> We identify that ZBTB42 is a prognostic biomarker for Low Grade Glioma and GBM and its function is related to the suppressive tumor microenvironment and stemness of glioma.</p>