AUTHOR=Qin Manman , Qian Yuqing , Huang Lu , Zhong Chao , Li Mingdong , Yu Jun , Chen Huanwen 

TITLE=Extractive electrospray ionization mass spectrometry for analytical evaluation and synthetic preparation of pharmaceutical chemicals

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1110900

DOI=10.3389/fphar.2023.1110900

ISSN=1663-9812

ABSTRACT=Extractive Electrospray Ionization Mass Spectrometry (EESI-MS) has been widely used in high throughput analysis of the integral component, pharmacokinetics, quality control and synthesis of pharmaceutical chemicals due to its unique configuration of the ionization assembly, which enables the effective ionization of the trace amount of molecules of interest in samples containing a complex matrix  with high sensitivity, specificity and fast response and allows the energetic molecular species to undergo dedicatedly designed reaction for advanced functionalization. The typical effect of operation conditions on the analytical performance of EESI-MS for various pharmaceutical compounds, different pharmaceutical preparations, and herb medicine materials has been systematically reviewed. The perspective of EESI application in unusual functionalization of molecules for advanced pharmaceutical chemicals is also briefly described.