AUTHOR=Yang Zhihua , Lin Shanshan , Liu Yangxi , Song Zhihui , Ge Zhao , Fan Yujian , Chen Lu , Bi Yingfei , Zhao Zhiqiang , Wang Xianliang , Wang Yi , Mao Jingyuan TITLE=Targeting intestinal microecology: potential intervention strategies of traditional Chinese medicine for managing hypertension JOURNAL=Frontiers in Pharmacology VOLUME=Volume 14 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1171119 DOI=10.3389/fphar.2023.1171119 ISSN=1663-9812 ABSTRACT=

Hypertension has become one of the major public health problems in the world. At present, the pathogenesis of hypertension has still not been completely elucidated. In recent years, an increasing evidence shows that intestinal microecology is closely related to hypertension, which provides a new thinking for the prevention and treatment of hypertension. Traditional Chinese medicine (TCM) has unique advantages in the treatment of hypertension. Taking intestinal microecology as the target, it is possible to interpreting the scientific connotation of TCM prevention and treatment of hypertension by updating the treatment concept of hypertension, so as to improve the therapeutic effect. In our study, the clinical evidence for TCM treatment of hypertension was systematicly summarized. And the relationship among TCM, intestinal microecology and hypertension was analyzed. In addition, the methods by which TCM regulates intestinal microecology to prevent and treat hypertension were presented, to provide new research ideas for prevention and treatment of hypertension.