AUTHOR=Yuan Ye , Liu Yamei , Hao Li , Ma Jinlian , Shao Simai , Yu Ziyang , Shi Ming , Zhang Zhenqiang , Zhang Zijuan 

TITLE=The neuroprotective effects of Liuwei Dihuang medicine in the APP/PS1 mouse model are dependent on the PI3K/Akt signaling pathway

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1188893

DOI=10.3389/fphar.2023.1188893

ISSN=1663-9812

ABSTRACT=Alzheimer's disease is an age-related neurodegenerative disease that progressively impairs cognitive function and memory. The occurrence and development of Alzheimer's disease (AD) involves many processes. In response to the complex pathogenesis of Alzheimer's disease, the traditional Chinese medicine formula LWD has been shown to improve the cognitive function of AD animal models. However, the active ingredients and mechanism of action of LWD have not been fully elucidated. In this study, network pharmacological analysis predicted 40 candidate compounds in LWD, acting on 227 potential targets, of which 185 were associated with AD. Through network pharmacological analysis, the mechanism of action of LWD therapy AD is related to the inhibition of inflammatory response, regulation of neuronal state, and autophagy. In this experiment, Liuwei Dihuang Pill (LWD) was detected in the APP/PS1 transgenic mouse model. The objective was to observe the effects of LWD on hippocampal learning and memory ability, Aβ