AUTHOR=Yuandani  , Jantan Ibrahim , Haque Md. Areeful , Rohani Ade Sri , Nugraha Sony Eka , Salim Emil , Septama Abdi Wira , Juwita Nur Aira , Khairunnisa Nur Aini , Nasution Halimah Raina , Utami Dinda Sari , Ibrahim Sarah 

TITLE=Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1222195

DOI=10.3389/fphar.2023.1222195

ISSN=1663-9812

ABSTRACT=Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices and flavouringflavoring agents and in ethnomedicine to heal numerous diseases including immune-related disorders. However, their ethnomedicinal uses have not been sufficiently supported by scientific investigations. Numerous studies on the modulating effects of the plantsplants and their bioactive compounds on the different steps of immune system have been documented. This review aimed to highlight up-to-date research findings and critically analyzedelaborate In this review, the modulatory effects and mechanisms of the extracts and secondary compounds of several Zingiber and Alpinia species, viz.