AUTHOR=Yan Mingyuan , Wu Jing , Wang Le , Wang Kaiyue , Li Lili , Sun Tianye , Zhang Han , Zhang Mi , Zou Lin , Yang Songyi , Liu Jinmin 

TITLE=Ginkgolide injections in meglumine, combined with edaravone, significantly increases the efficacy in acute ischemic stroke: A meta-analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1236684

DOI=10.3389/fphar.2023.1236684

ISSN=1663-9812

ABSTRACT=Except for intravenous thrombolysis, the effectiveness of western drugs for the treatment of acute ischemic stroke seems to be limited, and we are committed to investigate the effect of diterpene ginkgolides meglumine injection (DGMI) combined with edaravone on acute ischemic stroke. Methods: PubMed, Cochrane Library, Web of Science, CNKI, WanFang, VIP, and CBM databases were searched up to June 2023, data were analyzed using both fixed-effects and random-effects models by Review Manager. For each outcome, the mean difference (MD) with a 95% confidence interval (CI) was calculated. Results: Eighteen studies with 1,636 participants were included in this study. The DGMI group not only significantly reduced NIHSS (