AUTHOR=Wang Ke , Liao Pei-Yin , Chang Wei-Chun , Yang Cian-Ru , Su Yu-Ting , Wu Ping-Ching , Wu Yang-Chang , Hung Yao-Ching , Akhtar Najim , Lai Hsueh-Chou , Ma Wen-Lung 

TITLE=Linoleate-pazopanib conjugation as active pharmacological ingredient to abolish hepatocellular carcinoma growth

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1281067

DOI=10.3389/fphar.2023.1281067

ISSN=1663-9812

ABSTRACT=Small molecule compounds targeting multiple kinases involved in neoangiogenesis have shown survival benefits in patients with unresectable hepatocellular carcinoma (HCC). Nonetheless, despite the beneficial effects of multikinase inhibitors (MKIs), a lack of boosting adjuvant limits their objective response rate. Lipid conjugates have been used to improve delivery efficacy or pharmaceutical benefits for decades. However, the feasibility of utilizing lipid-drug conjugates (LDCs) in HCC regimens remains untested. In this study, oral feeding of linoleate-fluorescein isothiocyanate conjugates showed 已刪除: es