AUTHOR=Yang Shiyu , Chen Heming , Su Wei , Luo Yunchun , Liao Jun , Wang Yun , Xiong Liyan , Zhang Chuan , Li Fei , Chen Zhe-Sheng , Wang Tingfang 

TITLE=Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1297124

DOI=10.3389/fphar.2023.1297124

ISSN=1663-9812

ABSTRACT=Ischemia-reperfusion (I/R) injury refers to a new injury caused by reperfusion after the restoration of ischemic tissue or organ blood supply. Salvianic acid A (danshensu) is a primary active ingredient extracted from Salvia miltiorrhiza. It has a protective function against I/R injury in the cardiovascular system, brain, liver, kidney, gastrointestinal tract, and other organs. This article reviews evidence of the protective effects of Salvianic acid A and its potential mechanisms of action in organ I/R injury protection. The aim of this review is to investigate the role of Salvianic acid A in the treatment of I/R injury, providing a reference resource that could facilitate subsequent studies. This is a provisional file, not the final typeset article I/R injury is a challenging and life-threatening clinical problem that contributes to the pathology of a wide range of conditions [7][8]  . Previous studies have found that the underlying molecular mechanism of I/R injury involves various complex pathological processes, including complement system activation [9] , platelet-leukocyte aggregation [10][11]  , increased free radical production [12] , calcium overload [13] , mitochondrial membrane potential destruction [14] , reactive oxygen species (ROS) formation [15] , endothelial dysfunction [16] , and endoplasmic reticulum stress [17][18]  . Severe I/R injury can also cause cell death through the induction of necrosis, apoptosis, autophagy, and other pathways [19] . Although considerable progress has been made in recent years towards understanding the pathophysiology of I/R injury, safe and effective treatment methods are limited in clinical practice [20][21]  . Therefore, it is imperative to explore new drugs to control and treat I/R injury.