AUTHOR=De Pieri Marco , Ferrari Marco , Pistis Giorgio , Gamma Franziska , Marino Franca , Von Gunten Armin , Conus Philippe , Cosentino Marco , Eap Chin-Bin 

TITLE=Prediction of antipsychotics efficacy based on a polygenic risk score: a real-world cohort study

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1274442

DOI=10.3389/fphar.2024.1274442

ISSN=1663-9812

ABSTRACT=Response to antipsychotics is subject to a wide interindividual variability, due to genetic and nongenetic factors. Several single nucleotide polymorphisms (SNPs) have been associated with response to antipsychotics in genome-wide association studies (GWAS). Polygenic risk scores (PRS) are a powerful tool to aggregate into a single measure the small effects of multiple risk alleles.We studied the association between a PRS composed of SNPs associated with response to antipsychotics in GWAS studies (PRSresponse) in a real-world sample of patients (N=460) with different diagnoses (schizophrenia spectrum, bipolar, depressive, neurocognitive, substance use disorders and miscellaneous). Two other PRSs composed of SNPs previously associated with risk of schizophrenia (PRSschizophrenia1 and PRSschizophrenia2) were also tested for their association with response to treatment.PRSresponse was significantly associated with response to antipsychotics considering the whole cohort (OR=1.14, CI=1.03-1.26, P=0.010), the subgroup of patients with schizophrenia, schizoaffective disorder or bipolar disorder (OR=1.