AUTHOR=Wang Shuyun , Zhang Rui , Wang Song , Guo Qian , Yin Donghong , Song Yan , She Xianhua , Wang Xuyan , Duan Jinju 

TITLE=Osteonecrosis of the jaw in patients with clear cell renal cell carcinoma treated with targeted agents: a case series and large-scale pharmacovigilance analysis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1309148

DOI=10.3389/fphar.2024.1309148

ISSN=1663-9812

ABSTRACT=Objective: To optimize the use of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) for cancer patients, we characterized and evaluated ONJ related to TKIs and ICIs by analyzing a public database and reviewing the relevant literature. TKIs and ICIs are limited to drugs that treat renal cancer recommended by the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology for Kidney Cancer.We described a case series of patients experiencing ONJ while on TKIs or ICIs. We also