AUTHOR=Mottaghipisheh Javad , Kamali Marzie , Doustimotlagh Amir Hossein , Nowroozzadeh Mohammad Hossein , Rasekh Fatemeh , Hashempur Mohammad Hashem , Iraji Aida TITLE=A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L. JOURNAL=Frontiers in Pharmacology VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1322083 DOI=10.3389/fphar.2024.1322083 ISSN=1663-9812 ABSTRACT=Plants, renowned for their rich reservoir of metabolites, play a pivotal role in addressing health-related issues. The Verbenaceae family stands out, showcasing immense potential in preventing and treating chronic diseases. Vitex trifolia L. (V. trifolia), a shrub with a rich history in traditional medicine, particularly in Eastern Asia, has garnered attention for its diverse therapeutic applications. This comprehensive review aims to bridge traditional knowledge and contemporary insights by investigating ethnopharmacology, phytochemistry, and pharmacological effects of V. trifolia.The keyword ' V. trifolia ' and its synonyms were searched within the main scientific databases including