AUTHOR=Xu Weilin , Yan Jun , Travis Zachary D. , Lenahan Cameron , Gao Liansheng , Wu Haijian , Zheng Jingwei , Zhang Jianmin , Shao Anwen , Yu Jun 

TITLE=Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1352927

DOI=10.3389/fphar.2024.1352927

ISSN=1663-9812

ABSTRACT=The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.