AUTHOR=Qin Ziwen , Chen Yujuan , Liu Na , Wang Yonggang , Su Lili , Liang Bin , Huang Chuanjun 

TITLE=Mechanisms of Bushenyiqi decoction in the treatment of asthma: an investigation based on network pharmacology with experimental validation

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1361379

DOI=10.3389/fphar.2024.1361379

ISSN=1663-9812

ABSTRACT=This study was supported by the Natural Science Foundation of Shandong Province Youth Program of China (NO. ZR2023QH089). All people who contributed Conclusions: In conclusion, the integration of network pharmacology and biological experiments has demonstrated that key constituents of BYD, such as quercetin, kaempferol, and luteolin, exhibit targeted effects on IL-6, EGFR, and HIF1A in combating asthma-related inflammation through inhibition of the PI3K/AKT signaling pathway.The findings of this investigation provide evidence supporting the effectiveness of TCM's "bushenyiqi" therapy in asthma management, as corroborated by contemporary medical technology.