AUTHOR=Lin Yanting , Gao Rui , Jing Dongquan , Liu Yiming , Da Huijuan , Birnbaumer Lutz , Yang Yong , Gao Xinghua , Gao Zhenhua , Cao Qiuhua 

TITLE=TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1392328

DOI=10.3389/fphar.2024.1392328

ISSN=1663-9812

ABSTRACT=During the past half-century, although numerous interventions for obesity have arisen, the condition's prevalence has relentlessly escalated annually. Obesity represents a substantial public health challenge, especially due to its robust correlation with co-morbidities, such as colorectal cancer (CRC), which often thrives in an inflammatory tumor milieu. Of note, individuals with obesity commonly present with calcium and vitamin D insufficiencies.Transient receptor potential canonical (TRPC) channels, a subclass within the broader TRP family, function as critical calcium transporters in calcium-mediated signaling pathways. contributing to CRC development. This study provides valuable insights into the role and underlying mechanisms of TRPC deficiency in obesity and its related complication, CRC.Our findings offer a theoretical foundation for the prevention of adverse effects associated with TRPC inhibitors, potentially leading to new therapeutic strategies for obesity and CRC prevention.