AUTHOR=Wang Huan , Zheng Jiaqi , Zhang Qing , Tian Zhongping , Sun Yuhang , Zhu Tianyi , Bi Yanlong , Zhang Li 

TITLE=Efficacy and safety of complement inhibitors in patients with geographic atrophy associated with age-related macular degeneration: a network meta-analysis of randomized controlled trials

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1410172

DOI=10.3389/fphar.2024.1410172

ISSN=1663-9812

ABSTRACT=Importance: Clinical trials in recent years have shown great promise for geographic atrophy (GA) treatment though complement inhibitors. Two complement inhibitor drugs have been approved by the Food and Drug Administration. Objective: To compare and rank the different complement inhibitors in the treatment of GA secondary to age-related macular degeneration (AMD). Data Sources: A systematic literature search was conducted in the Cochrane Central, Web of Science Core Collection, PubMed, LWW Medical Journals, ClinicalTrials.gov and WHO ICTRP from inception to October 2023. Study Selection: All randomized clinical trials evaluating the effectiveness of complement inhibitors in patients diagnosed with secondary GA in AMD were identified.