AUTHOR=Chen Min , Xiao Yingying , Zheng Jijian , Zhao Peibin , Cheng Lin , Jiang Chuan , Zheng Sixie , Wang Zheng , Sun Sijuan , Ye Lincai , Chen Guozhen , Zhang Hao , Huang Yanhui 

TITLE=Cardioprotective effects of the electrolyte solution sterofundin and the possible underlying mechanisms

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1449831

DOI=10.3389/fphar.2024.1449831

ISSN=1663-9812

ABSTRACT=BackgroundSterofundin (SF) is one of the most widely used electrolyte solutions in almost all areas of medicine, with particular importance in intensive care. It provides powerful correction of acid-base imbalances, ion fluctuations, and impaired energy metabolism, which are the three most important characteristics after myocardial infarction (MI). However, whether and how SF protects the heart from post-MI damage are largely unknown.Methods and ResultsPretreating mice with SF before MI surgery reduced the number of reactive oxygen species (ROS)-positive and TUNEL-positive cells. As a result, the infarcted area cardiac fibrosis in the MI mice was reduced and cardiac performance in the MI mice improved. Moreover, RNA-seq analysis demonstrated that SF caused the gene expression profile of MI mice to shift toward that of sham mice, with a significant decrease in apoptosis-, ROS-, and inflammation-associated gene enrichment. RNA-seq analysis also demonstrated that SF induced the upregulation of autophagy-associated gene enrichment. Western blotting confirmed the RNA-seq analysis results, showing that SF induced the upregulation of an autophagic flux. When the autophagic flux was blocked with the autophagy inhibitor 3-methyladenine, the protective effect of SF was reduced.ConclusionSF protects the heart from post-MI damage, and one of the underlying mechanisms could be its autophagy modifications. This study is the first to reveal a previously unrecognized role of electrolyte solutions in post-MI intensive care.