This editorial aims to provide an overview of the complex process of angiogenesis and its implications for human health. Angiogenesis is a complex process with far-reaching implications for human health. Its dysregulation can contribute to a myriad of diseases, including cancer, diabetic retinopathy, and impaired wound repair (Pessolano et al., 2018; Pessolano et al., 2021; Belvedere et al., 2022). Huang et al. demonstrated melatonin’s efficacy in promoting angiogenesis, suggesting a promising avenue for reconstructive surgery. Indeed, in his work, Ribatti’s points the attention on tumor vasculature, revealing critical differences between healthy and cancerous vessels, offering targets for anti-cancer therapies. Finally, the importance of the pharmacological modulation of angiogenesis in pathological conditions is explored. Ocular neovascularization represents an important Research Topic in the loss of vision. The anti-angiogenic and antioxidant effects of axitinib are analysed and suggested as potential treatment for diabetic retinopathy by Lazzara et al.
Deng et al. instead focuses on the ability of LSD-1 in controlling corneal neovascularization, identifying a potential therapeutic target. These studies collectively underscore the multifaceted nature of angiogenesis and its potential as a therapeutic target across various diseases.
Statements
Author contributions
EP: Writing–original draft, Writing–review and editing. RB: Writing–original draft, Writing–review and editing. SS: Writing–original draft, Writing–review and editing.
Funding
The authors declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
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BelvedereR.NovizioN.MorelloS.PetrellaA. (2022). The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk. Sci. Rep.12 (1), 11041. 10.1038/s41598-022-15227-1
2
PessolanoE.BelvedereR.BizzarroV.FrancoP.MarcoI.PortaA.et al (2018). Annexin A1 may induce pancreatic cancer progression as a key player of extracellular vesicles effects as evidenced in the in vitro MIA PaCa-2 model system. Int. J. Mol. Sci.19 (12), 3878. 10.3390/ijms19123878
3
PessolanoE.BelvedereR.NovizioN.FilippelliA.PerrettiM.WhitefordJ.et al (2021). Mesoglycan connects Syndecan-4 and VEGFR2 through Annexin A1 and formyl peptide receptors to promote angiogenesis in vitro. FEBS J.288 (22), 6428–6446. 10.1111/febs.16043
Summary
Keywords
angiogenesis, tumor vasculature, diabetic retinopathy, corneal neovascularisation, pharmacological modulation
Citation
Pessolano E, Belvedere R and Spampinato SF (2024) Editorial: The pharmacological modulation of angiogenesis. Front. Pharmacol. 15:1474918. doi: 10.3389/fphar.2024.1474918
Received
02 August 2024
Accepted
20 August 2024
Published
27 August 2024
Volume
15 - 2024
Edited and reviewed by
Filippo Drago, University of Catania, Italy
Updates
Copyright
© 2024 Pessolano, Belvedere and Spampinato.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Emanuela Pessolano, emanuela.pessolano@uniupo.it
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.