AUTHOR=He Chengyi , Chen Yunfei , Xie Jiao , Luo Miao , Fisher David , Hien Nguyen Thi Thu , Musabaev Erkin , Dang Yiping , Zhao Lei , Xia Yin 

TITLE=Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 15 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1488003

DOI=10.3389/fphar.2024.1488003

ISSN=1663-9812

ABSTRACT=Dihydromyricetin (DHM or DMY) is a flavonoid derived from natural sources with a range of confirmed biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. DHM is recognized for its high biosafety, making it a promising subject for further research. This article offers a comprehensive overview of DHM’s pharmacological properties, mechanisms, and recent research developments in the cardiovascular, urinary, digestive, nervous, and respiratory systems. The review summarizes DHM’s biological effects and associated signaling pathways, providing novel insights for its clinical application.