AUTHOR=Shi Wei , Xu Yang , Wei Jian , Zhang Xiaoyu , Zhu Shuaijie , Guo Heng , Huang Qihui , Qi Chuyao , Hua Tianfeng , Liu Yue , Yang Min 

TITLE=Plant-derived secondary metabolites and nanotechnology: innovative strategies and emerging challenges in myocardial ischemia-reperfusion injury therapy

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1529478

DOI=10.3389/fphar.2025.1529478

ISSN=1663-9812

ABSTRACT=Therapy for acute myocardial infarction often causes myocardial ischemia-reperfusion injury (MIRI), which is characterized by oxidative stress, inflammation, and apoptosis. Traditional therapies have shown poor effectiveness because of their low absorption and inappropriate targeting. Recently, nanotechnology has emerged as a promising treatment option for MIRI. Nanocarriers, such as liposomes, polymers, inorganic nanoparticles, and hybrid nanoparticles, make therapies more effective by making drugs more stable, improving targeting accuracy and lowering side effects. Plant-derived secondary metabolites and nanoparticles, specifically those containing Panax notoginseng saponins and flavonoids, have been shown to work together as a therapeutic approach. These nanoparticles have antioxidant, anti-inflammatory, and anti-apoptotic properties that significantly reduce myocardial injury after reperfusion. Targeting specificity and safety limit clinical translation, even with significant technological developments in these areas. Herein, we review current studies on nanocarriers and plant-derived secondary metabolite nanoparticles for MIRI treatment, as well as potential future clinical applications and limitations.