AUTHOR=Li Haotian , Xia Congmin , Hou Youjuan , Hu Sile , Liu Yanjun , Jiang Quan 

TITLE=TCMRD - KG: innovative design and development of rheumatology knowledge graph in ancient Chinese literature assisted by large language models

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1535596

DOI=10.3389/fphar.2025.1535596

ISSN=1663-9812

ABSTRACT=IntroductionRheumatic immune diseases are a type of immune-inflammatory disease that affects muscles, bones, joints, and surrounding soft tissues. They have a long course and a high disability rate, seriously affecting the quality of life of patients. Traditional Chinese medicine plays an important role in the diagnosis and treatment of rheumatic immune diseases. The unique theoretical system and rich treatment methods of traditional Chinese medicine are preserved in ancient Chinese medical books.MethodsThis study takes the content related to rheumatism in ancient traditional Chinese medicine books as the research object, integrates ontology theory and technology into the knowledge graph, and realizes the reconstruction of traditional Chinese medicine information knowledge. It provides a basic data structure for data mining and knowledge discovery.ResultsThis study is the first rheumatism-specific knowledge graph constructed based on ancient traditional Chinese medicine books. It has explored the construction method of a knowledge graph from ancient books by combining automatic labeling of mainstream large language models with manual review. Considering the knowledge characteristics of ancient traditional Chinese medicine books, where existing word segmentation technology struggles to accurately reproduce the original meaning, a new type of entity extraction method is proposed.DiscussionThis provides an important foundation for improving the clinical diagnosis and treatment level of traditional Chinese medicine in treating rheumatism, further exploring the knowledge representation and application of traditional Chinese medicine in rheumatism treatment, and it has potential for future expansion and improvement.