AUTHOR=Duan Liguang , An Feiyue , Tian Chen , Yan Wen , Chen Jie , Zhang Hongyin , Liu Xiaoguang , Wang Lingjiao , Zhang Zhuo , Tong Binliang , Zhou Chunhua 

TITLE=Post-marketing safety re-evaluation of placental peptide injection in China: a large-scale multicenter real-world study

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1541005

DOI=10.3389/fphar.2025.1541005

ISSN=1663-9812

ABSTRACT=PurposeThis study conducted a post-marketing safety re-evaluation of placental polypeptide injections in China to support updates to drug guidelines, pharmacovigilance efforts, and rational clinical use, facilitating its inclusion in essential drug lists and medical insurance coverage.MethodsA hospital-based centralized monitoring system tracked 3,000 patients receiving placental polypeptide injections across three medical institutions. Adverse drug reactions (ADRs) and adverse drug events (AEs) were systematically collected and analyzed.ResultsThe mean patient age was 49.65 years, with 96.47% being over 18 years of age. A single dose exceeding 4 mL was administered in 98.34% of the cases, with a median treatment duration of 7 days. Concomitant medication use was high (injectable, 98.43%; non-injectable, 75.43%). One case of vertigo was reported as an ADR in a patient aged >60 years who had melanoma.ConclusionThe ADR rate was 0.03%, confirming the favorable safety profile of placental polypeptide injection. These findings support its safe clinical use and can inform future regulatory and policy decisions.