AUTHOR=Xu Yiyang , Yang Siyuan , Rao Qi , Gao Yuan , Zhou Guanyue , Zhao Dongmei , Shi Xinsheng , Chai Yi , Zhao Chen TITLE=A mechanistic quantitative systems pharmacology model platform for translational efficacy evaluation and checkpoint combination design of bispecific immuno-modulatory antibodies JOURNAL=Frontiers in Pharmacology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1571844 DOI=10.3389/fphar.2025.1571844 ISSN=1663-9812