AUTHOR=Jiang Yucai , Wen Guolin Alexander TITLE=Deciphering gene mutations in the efficacy and toxicity of antineoplastic drugs: an oncology pharmacist’s perspective JOURNAL=Frontiers in Pharmacology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1574010 DOI=10.3389/fphar.2025.1574010 ISSN=1663-9812 ABSTRACT=Background/ObjectivesThis article reviews some key emerging pharmacogenomic topics in oncology pharmacy practice.MethodsPublications selected to review were mainly sourced from the new drug approvals by the Food and Drug Administration and the new regimens listed in the National Comprehensive Cancer Network.ResultsKey pharmacogenomic topics were presented, including genetic alterations influencing drug metabolism, drug efficacy, and changes in therapeutic targeting; Relevant clinical updates and advancements were summarized to provide an in-depth understanding.ConclusionThe abundance of pharmacogenomic measures builds a solid foundation and heralds a paradigm shift toward individualized patient care.