AUTHOR=Fu Jie , Zhang Chi 

TITLE=The research progress on radionuclides in osteoporosis diagnosis and drug efficacy monitoring

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1594903

DOI=10.3389/fphar.2025.1594903

ISSN=1663-9812

ABSTRACT=Osteoporosis is a common metabolic bone disease that seriously affects the quality of life and health of patients. Traditional diagnostic methods, such as dual energy X-ray absorptiometry (DXA), have limitations in early detection and dynamic monitoring, making it difficult to meet clinical needs. This paper focuses on the potential of radionuclide imaging techniques, such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET), in the early diagnosis of osteoporosis. The paper further elaborates on the importance of radionuclides in evaluating the therapeutic effect of osteoporosis drugs. By summarizing current research findings, this paper aims to emphasize the core role of radionuclides in the management of osteoporosis, and provide theoretical basis and practical guidance for optimizing the diagnosis and treatment strategies of bone metabolism diseases in the future.