AUTHOR=Fan Ke-Qin , Zhang Liangming , Song Fangyu , Zhang Yue-Hui , Chen Tong , Cheng Xiang , Su Ning , Zou Yan , Yu Ting , Tan Futing , Xu Wenhao , Yan Zijun 

TITLE=Pharmacological properties and therapeutic potential of berberine: a comprehensive review

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1604071

DOI=10.3389/fphar.2025.1604071

ISSN=1663-9812

ABSTRACT=In recent decades, the pharmacological properties of botanical drugs have been investigated with increasing depth, offering novel insights into their potential for enhancing healthcare. Berberine (BBR) is an alkaloid extracted from the roots, rhizomes and stem tubers of plants such as Coptis chinensis, Phellodendron amurense, Radix berberidis, and several other plants, which is used not only as an anti-inflammatory and antibacterial agent, but also for the treatment of cancer and chronic diseases. BBR has demonstrated remarkable therapeutic efficacy in the management of disorders affecting the nervous, cardiovascular, and endocrine systems, characterized by its high safety profile and minimal adverse effects. Despite the substantial progress made in understanding BBR’s pharmacodynamics, its precise mechanisms of action remain incompletely elucidated and warrant further systematic investigation. This study provides an extensive review of the latest pharmacological findings related to berberine and its therapeutic advancements, offering strong evidence for future research and clinical implementation.