AUTHOR=Yu Binrui , Wang Nailong , Cai Shanshan , Yan Hao , Sun Shaojia , Wang Siru , Li Ye , Liang Zhengting 

TITLE=Research progress on peptides that inhibit melanin synthesis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1610623

DOI=10.3389/fphar.2025.1610623

ISSN=1663-9812

ABSTRACT=Melanin produced by melanocytes, primarily determines human skin color and protects against ultraviolet radiation. However, excessive melanin deposition can lead to skin conditions such as freckles, age spots, and moles, potentially causing aesthetic concerns and psychological distress. Consequently, there is significant research interest in developing safe and effective whitening products that inhibit melanin synthesis. Bioactive peptides represent a promising compound category that effectively reduces melanin synthesis with minimal side effects. This review explores melanin pigmentation, identifies sources of peptides that inhibit melanin synthesis, and elucidates the mechanisms by which these peptides operate, aiming to contribute to developing novel whitening products.