AUTHOR=Selc Michal , Babelova Andrea TITLE=Looking beyond silybin: the importance of other silymarin flavonolignans JOURNAL=Frontiers in Pharmacology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1637393 DOI=10.3389/fphar.2025.1637393 ISSN=1663-9812 ABSTRACT=Silymarin, an extract from the seeds of milk thistle (Silybum marianum), has been widely studied and used for its hepatoprotective and pharmacological properties. For decades, both experimental and clinical research has been predominantly focused on a single component, silybin, while other related flavonolignans, such as silychristin, isosilybins, silydianin, dehydrosilybin, and the flavonoid taxifolin, have been understudied. However, these less known components may possess unique or even superior pharmacological activities compared to silybin, including strong antioxidant, anti-inflammatory, antiviral, and selective anticancer effects. Exploring these other constituents beyond silybin may unlock new opportunities for drug discovery and personalized phytotherapy, ultimately advancing the development of next-generation flavonolignan-based therapeutics.