AUTHOR=Guo Shuang , Zhao Junlai , Zhu Rongrong , Fan Zhi , Liu Shibiao , Wu Weiwei 

TITLE=Epigenetic modifications of gut microbiota and their potential role in atherosclerosis

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1638240

DOI=10.3389/fphar.2025.1638240

ISSN=1663-9812

ABSTRACT=Emerging evidence positions the gut microbiota as a pivotal regulator of host metabolism and immunity, particularly in atherosclerosis pathogenesis, with epigenetic mechanisms serving as fundamental mediators of gene expression control. This review systematically summarizes gut microbiome-driven epigenetic pathways, encompassing DNA methylation, histone modifications, non-coding RNA networks and their interplay with atherosclerosis-related pathological processes. We synthesize current evidence on microbiota-epigenome crosstalk, highlighting its potential mechanistic contributions to atherosclerotic plaque development.