AUTHOR=Hashemi Mohamad Javad , Dhaouadi Khattab Yousr , Ren Dacheng 

TITLE=Mini review: Persister cell control strategies

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1706115

DOI=10.3389/fphar.2025.1706115

ISSN=1663-9812

ABSTRACT=Bacterial persisters are growth-arrested cells with low metabolic activities, but have no genetic mutations compared to their parental cells. The dormant nature of persister cells enables them to tolerate high doses of conventional antibiotics and restart growth after the antibiotic is withdrawn, posing an important challenge to infection control. To promote more research in this important area, we present a concise review of current persister control strategies and discuss future opportunities.