Original Research

Published on 16 Feb 2024

New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway

in Experimental Pharmacology and Drug Discovery

Badriyah S. Alotaibi
Thanaa A. El-Masry
Hend Selim
Maisra M. El-Bouseary
Mostafa M. El-Sheekh
Mofida E. M. Makhlof
Maysa M. F. El-Nagar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1345516

1,744 views
1 citation

Original Research

Published on 16 Feb 2024

Predicting pharmacodynamic effects through early drug discovery with artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) modelling

in Experimental Pharmacology and Drug Discovery

Keheng Wu
Xue Li
Zhou Zhou
Youni Zhao
Mei Su
Zhuo Cheng
Xinyi Wu
Zhijun Huang
Xiong Jin
Jingxi Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1330855

2,956 views
1 citation

Editorial

Published on 16 Feb 2024

Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery

in Experimental Pharmacology and Drug Discovery

Michelle Khai Khun Yap
Cassandra M. Modahl
Steven R. Hall

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1380193

669 views

Original Research

Published on 16 Feb 2024

Prediction of multiple types of drug interactions based on multi-scale fusion and dual-view fusion

in Experimental Pharmacology and Drug Discovery

Dawei Pan
Ping Lu
Yunbing Wu
Liping Kang
Fengxin Huang
Kaibiao Lin
Fan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1354540

1,294 views

Review

Published on 16 Feb 2024

Recent advances in drug delivery of celastrol for enhancing efficiency and reducing the toxicity

in Experimental Pharmacology and Drug Discovery

Yuan Sun
Chengen Wang
Xiaoguang Li
Jun Lu
Maolin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1137289

1,417 views
3 citations

Original Research

Published on 15 Feb 2024

Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes

in Experimental Pharmacology and Drug Discovery

Yang Songtao
Li Fangyu
Cao Jie
Yuan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1370708

1,557 views
1 citation

Original Research

Published on 15 Feb 2024

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders

in Experimental Pharmacology and Drug Discovery

Mohammed Alissa
Ahmed Hjazi
Ghadah S. Abusalim
Ghfren S. Aloraini
Suad A. Alghamdi
Nahed S. Alharthi
Waleed Y. Rizg
Khaled M. Hosny
Nada Binmadi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1347551

1,800 views

Original Research

Published on 15 Feb 2024

Network pharmacology, molecular simulation, and binding free energy calculation-based investigation of Neosetophomone B revealed key targets for the treatment of cancer

in Experimental Pharmacology and Drug Discovery

Abbas Khan
Yasir Waheed
Shilpa Kuttikrishnan
Kirti S. Prabhu
Tamam El-Elimat
Shahab Uddin
Feras Q. Alali
Abdelali Agouni

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1352907

2,061 views

Review

Published on 14 Feb 2024

Combating antimicrobial resistance: the silent war

in Experimental Pharmacology and Drug Discovery

Letao Bo
Haidong Sun
Yi-Dong Li
Jonathan Zhu
John N. D. Wurpel
Hanli Lin
Zhe-Sheng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1347750

2,780 views
2 citations

Original Research

Published on 13 Feb 2024

Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

in Experimental Pharmacology and Drug Discovery

Osama M. Alshehri
Anwar Zeb
Syed Muhammad Mukarram Shah
Mater H. Mahnashi
Saeed Ahmed Asiri
Omaish Alqahtani
Abdul Sadiq
Muhammad Ibrar
Saleh Alshamrani
Muhammad Saeed Jan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1328128

1,524 views
5 citations

Data Report

Published on 12 Feb 2024

Leniolisib: a novel treatment for activated phosphoinositide-3 kinase delta syndrome

in Experimental Pharmacology and Drug Discovery

Surya K. De

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1337436

2,220 views

Original Research

Published on 09 Feb 2024

Knockdown of EIF4G1 in NSCLC induces CXCL8 secretion

in Experimental Pharmacology and Drug Discovery

Ziyang He
Fangyi Li
Xinyi Zhang
Dacheng Gao
Zhiwen Zhang
Rui Xu
Xingguo Cao
Qiyuan Shan
Zhen Ren
Yali Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1346383

1,472 views

Correction

Published on 09 Feb 2024

Corrigendum: Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease

in Experimental Pharmacology and Drug Discovery

Weiwei Lin
Fatemeh Mousavi
Benjamin C. Blum
Christian F Heckendorf
Jarrod Moore
Noah Lampl
Mark McComb
Sergei Kotelnikov
Wenqing Yin
Nabil Rabhi

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1376058

1,079 views

Editorial

Published on 08 Feb 2024

Editorial: Augmented neuro-therapy with nanotechnology-based formulations: progress, opportunities and challenges

in Experimental Pharmacology and Drug Discovery

Mithun Singh Rajput
Viral Patel
Nilesh Prakash Nirmal
Dileep Kumar

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1376878

773 views

Review

Published on 07 Feb 2024

Generative artificial intelligence in drug discovery: basic framework, recent advances, challenges, and opportunities

in Experimental Pharmacology and Drug Discovery

Amit Gangwal
Azim Ansari
Iqrar Ahmad
Abul Kalam Azad
Vinoth Kumarasamy
Vetriselvan Subramaniyan
Ling Shing Wong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1331062

8,370 views
3 citations

Original Research

Published on 07 Feb 2024

Overexpression of CXCL17 increases migration and invasion of A549 lung adenocarcinoma cells

in Experimental Pharmacology and Drug Discovery

Ekin Koni
Irem Congur
Zeynep Tokcaer Keskin

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1306273

1,601 views

Navigation group

Articles

New insights into the anticancer effects of Polycladia crinita aqueous extract and its selenium nanoformulation against the solid Ehrlich carcinoma model in mice via VEGF, notch 1, NF-кB, cyclin D1, and caspase 3 signaling pathway

Predicting pharmacodynamic effects through early drug discovery with artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) modelling

Editorial: Experimental and computational aspects of bioactive proteins from animal venoms: an insight into pharmacological properties and drug discovery

Prediction of multiple types of drug interactions based on multi-scale fusion and dual-view fusion

Recent advances in drug delivery of celastrol for enhancing efficiency and reducing the toxicity

Identification of claudin-2 as a promising biomarker for early diagnosis of pre-diabetes

Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders

Network pharmacology, molecular simulation, and binding free energy calculation-based investigation of Neosetophomone B revealed key targets for the treatment of cancer

Combating antimicrobial resistance: the silent war

Investigation of anti-nociceptive, anti-inflammatory potential and ADMET studies of pure compounds isolated from Isodon rugosus Wall. ex Benth

Leniolisib: a novel treatment for activated phosphoinositide-3 kinase delta syndrome

Knockdown of EIF4G1 in NSCLC induces CXCL8 secretion

Corrigendum: Integrated metabolomics and proteomics reveal biomarkers associated with hemodialysis in end-stage kidney disease

Editorial: Augmented neuro-therapy with nanotechnology-based formulations: progress, opportunities and challenges

Generative artificial intelligence in drug discovery: basic framework, recent advances, challenges, and opportunities

Overexpression of CXCL17 increases migration and invasion of A549 lung adenocarcinoma cells